Product Name: 2-Ethoxyethylamine
Chemical Formula: C4H11NO
CAS Number: 110-76-9
EC Number: 203-802-2
Synonyms: Ethyl cellosolve amine, 2-Ethoxyethanamine, beta-Ethoxyethylamine
Recommended Use: Intermediate in organic synthesis, laboratory reagent
Supplier: Refer to label or invoice for manufacturer identification
Emergency Contact: Refer to local regulations or on-site safety number
Classification: Flammable liquid (Category 3), Acute Toxicity (Oral, Category 4), Skin Irritation (Category 2), Eye Irritation (Category 2A)
Label Elements: Pictograms – Flame, Exclamation mark
Signal Word: Warning
Hazard Statements: Causes moderate skin irritation. Harmful if swallowed. Causes eye irritation. Flammable liquid and vapor.
Precautionary Statements: Keep away from heat, sparks, open flames. Wear protective clothing and eye protection. Avoid breathing vapors or spray. If on skin, wash immediately. In case of fire, use dry chemical, CO2, alcohol foam.
Chemical Name: 2-Ethoxyethylamine
Concentration: ≥98% by weight
Impurities: Minor impurities may include water and related amines, present below 2% total
Additives: None specifically added for stabilization
Inhalation: Move person to fresh air. If respiratory irritation, cough or other symptoms develop, seek medical advice. Loosen tight clothing and keep warm.
Skin Contact: Remove contaminated clothing, wash affected area with soap and water for at least 15 minutes. If symptoms persist, consult a healthcare provider.
Eye Contact: Flush with running water for no less than 15 minutes, lifting eyelids occasionally. Remove contacts if safe to do so. Continue rinsing and get medical attention.
Ingestion: Rinse mouth with water, give small amount of water to drink if conscious. Do not induce vomiting. Seek immediate medical assistance.
Indication of Immediate Medical Attention: Irritation, breathing difficulty, or signs of toxicity require prompt treatment.
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, alcohol-resistant foam, water fog.
Unsuitable Extinguishing Media: Strong water jets may spread material.
Specific Hazards: Vapors may form explosive mixtures with air. Hazardous combustion products include nitrogen oxides, carbon monoxide, carbon dioxide.
Special Protective Equipment for Firefighters: Use full protective gear, including self-contained breathing apparatus.
Advice for Firefighters: Approach fire from upwind to avoid toxic fumes. Cool containers with water spray if safe to do so.
Personal Precautions: Evacuate unnecessary personnel, ventilate area, control sources of ignition. Wear suitable chemical-resistant gloves, goggles, and protective clothing.
Spill Response: Contain and absorb with inert material such as activated carbon, sand, or vermiculite. Avoid runoff into drains, soil, or waterways.
Cleanup Methods: Collect contaminated materials and transfer to properly labeled, sealable waste containers. Clean affected area with water and mild detergent.
Emergency Procedures: Alert local emergency response if large-scale spill. Ensure proper ventilation.
Safe Handling: Use only in well-ventilated zones or with exhaust ventilation. Avoid inhalation of vapors, direct contact with skin or eyes. Ground and bond containers during transfers. Prevent the buildup of static charges.
Storage: Store tightly sealed in a cool, dry, well-ventilated location. Keep containers away from heat, open flames, and oxidizing agents. Maintain temperature controls if possible. Store in compatible containers (preferably glass or specific plastics).
Incompatibilities: Store away from acids, strong oxidizers, peroxides, and acyl halides to avoid dangerous reactions.
Occupational Exposure Limits: No established OSHA/ACGIH exposure limits; observe good industrial hygiene practice.
Engineering Controls: Mechanical exhaust, local ventilation, fume hood or effective air exchange required for indoor use.
Personal Protective Equipment: Chemical safety goggles, face shield for splash potential, nitrile or butyl rubber gloves, flame-resistant lab coat, closed footwear.
Respiratory Protection: Use NIOSH-approved respirator if vapor concentrations are likely to exceed safe levels.
Hygiene Measures: Wash hands thoroughly after handling, removal of contaminated clothing before food breaks or end of shift.
Appearance: Colorless to pale yellow liquid
Odor: Amine-like, slightly ether-like odor
pH (1% solution): Slightly alkaline
Boiling Point: 130–134°C
Melting Point: -70°C
Flash Point: 38°C (closed cup)
Vapor Pressure: 6 mm Hg at 25°C
Vapor Density: 2.6 (air=1)
Solubility: Completely miscible with water, alcohols, and many organic solvents
Specific Gravity: 0.88–0.91 (water=1)
Auto-Ignition Temperature: 230°C
Partition Coefficient: log Kow = -0.32
Evaporation Rate: Not established; considered moderate based on volatility
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Reacts with strong oxidizing agents, acids, acyl halides, and acid chlorides.
Potential Hazardous Reactions: Exothermic polymerization or decomposition may occur with incompatible substances.
Decomposition Products: Carbon oxides, nitrogen oxides, and other hazardous gases produced under fire or extreme heat.
Conditions to Avoid: Heat, sparks, flames, incompatible substances, poorly ventilated areas above ambient temperature.
Acute Toxicity: Oral LD50 (rat): 420 mg/kg; Dermal LD50 (rabbit): >2000 mg/kg
Symptoms of Exposure: Eye, skin, and respiratory irritation, cough, headache, dizziness, nausea.
Chronic Effects: Prolonged or repeated exposure may cause dermatitis and possible liver or kidney impacts in animal models.
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA.
Mutagenicity: No data indicating mutagenic effects.
Reproductive Toxicity: Animal studies suggest potential developmental effects at high exposure; recommend minimizing exposure in pregnant individuals.
Routes of Exposure: Inhalation, dermal, ingestion, ocular.
Target Organs: Eyes, skin, central nervous system, liver, kidneys.
Environmental Fate: Rapidly biodegradable in standard sewage treatment (half-life days). Substantial volatilization from water surfaces. Not persistent in soil.
Mobility: Readily mobile in most soil types due to water solubility.
Aquatic Toxicity: LC50 (fish, 96h): 140 mg/L. EC50 (daphnia, 48h): 97 mg/L. Moderate hazard to aquatic life at high concentrations.
Bioaccumulation: Low potential (log Kow <0)
Other Hazards: High oxygen demand if released in bulk to water, may affect wastewater treatment operations.
Waste Treatment: Small amounts may be neutralized and flushed with excess water under permit. Large amounts should be collected by licensed waste contractors.
Contaminated Packaging: Rinse containers three times before disposal, remove labels, puncture or crush before recycling where permitted.
Disposal Restrictions: Do not pour into drains, watercourses, or soil.
Regulatory Disposal: Follow local, national, and regional waste regulations for classification as hazardous or non-hazardous waste.
UN Number: UN2733
Proper Shipping Name: 2-Ethoxyethylamine
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Labels: Flammable liquid
Marine Pollutant: No
Special Precautions for Transport: Avoid direct sunlight, high temperatures, and rough handling. Use corrosion-resistant containers. Follow all international transport codes (ADR, IMDG, IATA).
Occupational Safety Regulations: Listed as hazardous by OSHA and EU Classification. Not subject to REACH authorization but requires safety training.
TSCA Status: Listed in the US Toxic Substances Control Act inventory.
EINECS/ELINCS: Listed in European inventory.
Canadian DSL/NDSL: Present on Domestic Substances List.
SARA Title III: Not listed under Section 313.
State Regulations: May be regulated by individual US states.
Other International: Complies with major chemical control regulations (Australia AICS, Japan ENCS, China IECSC). Always reference most up-to-date local, regional, and national regulations before use or disposal.
