Product Name: 5-Methyl-2-hexanone
Synonyms: 2-Hexanone, 5-methyl-; Methyl isoamyl ketone
Chemical Family: Aliphatic ketone
CAS Number: 110-12-3
Molecular Formula: C7H14O
Recommended Use: Industrial solvent, intermediate in chemical synthesis
Manufacturer or Supplier Details: Available upon request—includes company address, emergency phone, and technical service contact.
GHS Classification: Flammable liquid (Category 3), Acute toxicity oral (Category 4), Eye irritation (Category 2A), Specific target organ toxicity (nervous system)
Label Elements: Flammable pictogram, exclamation mark
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor; Harmful if swallowed; Causes serious eye irritation; May cause drowsiness or dizziness
Precautionary Statements: Avoid breathing fumes, vapors; Wash hands thoroughly after handling; Keep container tightly closed; Use proper ventilation; Wear protective gloves, clothing, and eye protection.
Routes of Entry: Inhalation, ingestion, skin contact, eye contact
Pictograms: Flame; Exclamation mark
Chemical Name: 5-Methyl-2-hexanone
CAS Registry Number: 110-12-3
Concentration: 95 – 100%
Impurities: May contain trace amounts of related ketones and alkanes
Stabilizers/Additives: None reported
Inhalation: Move to fresh air, keep patient at rest, provide oxygen if available, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing and rinse skin with plenty of soap and water, seek medical advice if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, get medical advice
Ingestion: Rinse mouth thoroughly, do not induce vomiting, give water if conscious, seek medical attention
Important Symptoms and Effects: Headache, dizziness, nausea, vomiting, respiratory tract irritation
Notes to Physician: Treat symptomatically, possible risk of aspiration and CNS effects
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical powder, carbon dioxide, water spray (do not use direct water stream)
Unsuitable Media: Direct water jets
Hazardous Combustion Products: Carbon oxides, irritating toxic fumes
Protective Equipment for Firefighters: Full protective gear and positive pressure self-contained breathing apparatus
Fire Hazards: Vapors can form explosive mixture with air, may flow to distant sources of ignition
Special Measures: Cool exposed containers with water spray to prevent fire spread, evacuate area if necessary
Personal Precautions: Evacuate unnecessary personnel, use suitable personal protection as outlined in section “Exposure Controls and Personal Protection”, avoid breathing vapors, ventilate area
Environmental Precautions: Prevent from entering drains, waterways, and soil, notify authorities if significant spillage occurs
Methods for Cleaning Up: Absorb spill with inert material like sand or vermiculite, place in suitable closed container for disposal, wash area with plenty of water, ventilate area
Handling Procedures: Avoid contact with skin, eyes, and clothing, use with adequate ventilation, keep away from heat, sparks, open flames, and static discharge sources, ground containers during transfer
Storage Recommendations: Store in tightly closed containers, in a cool and well-ventilated place, away from incompatible materials such as oxidizing or acidic agents
Other Precautions: Use explosion-proof equipment, empty containers may contain hazardous residues
Occupational Exposure Limits: No established OSHA or ACGIH limits; recommended 20 ppm TWA by internal guideline
Engineering Controls: Use mechanical ventilation, fume hood, or explosion-proof exhaust system as needed
Respiratory Protection: Wear approved organic vapor respirator for high concentrations or insufficient ventilation
Skin Protection: Wear chemical-resistant gloves (nitrile, neoprene), protective clothing
Eye Protection: Chemical splash goggles or face shield
Hygiene Measures: Wash hands and face after handling, remove contaminated clothing and wash before re-use
Appearance: Colorless liquid
Odor: Mild, sweet, ketone-like odor
Odor Threshold: Data not available
pH: Not applicable
Melting Point/Freezing Point: -64°C
Boiling Point/Range: 144–145°C
Flash Point: 40°C (closed cup)
Evaporation Rate: 0.75 (n-butyl acetate = 1)
Flammability: Flammable liquid
Upper/Lower Flammable Limits: 1.2% / 7.3% (volume in air)
Vapor Pressure: 3 mmHg at 20°C
Vapor Density: 3.5 (air = 1)
Relative Density: 0.81 at 20°C
Solubility in Water: Slightly soluble
Partition Coefficient (n-octanol/water): Log Kow estimated at 1.32
Auto-Ignition Temperature: 425°C
Decomposition Temperature: Not established
Viscosity: 0.73 mPa·s at 25°C
Chemical Stability: Stable under normal conditions of storage and use
Reactivity: Reacts with strong acids and oxidizing agents
Hazardous Reactions: May generate explosive peroxides in air
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possibly toxic fumes
Conditions to Avoid: Heat, sparks, flame, static discharge, prolonged exposure to air or light
Incompatible Materials: Strong oxidizers, strong acids, bases, amines
Acute Toxicity: Oral LD50 (rat): 1600 mg/kg; Dermal LD50 (rabbit): 3400 mg/kg; Inhalation LC50: Not established
Skin Contact: May cause mild irritation
Eye Contact: Causes moderate to severe irritation
Ingestion: Harmful, central nervous system depression possible
Chronic Effects: Repeated exposure may cause liver, kidney, and nervous system effects
Carcinogenicity: Not listed by IARC, NTP, OSHA
Mutagenicity: No data available
Reproductive Toxicity: No adequate information
Symptoms and Effects: Headache, nausea, dizziness, fatigue, irritation of mucous membranes
Ecotoxicity: Toxic to aquatic organisms at moderate concentrations, may cause long-term adverse effects in aquatic environment
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulative Potential: Potential for bioaccumulation is low (Log Kow 1.32)
Mobility in Soil: High mobility due to low adsorption
Other Adverse Effects: Release into environment can affect water quality, long-term monitoring advised in spills
Waste Disposal Methods: Dispose of as hazardous waste in accordance with local, state, and federal regulations, incineration preferred for larger quantities, avoid release to sewage or landfill
Container Disposal: Empty containers retain product vapor and residue, triple rinse and offer for recycling if possible or dispose of in line with regulatory requirements
Precautions: Avoid accumulation of vapors, consult approved waste contractor, do not attempt open burning
UN Number: UN 1110
UN Proper Shipping Name: 5-Methyl-2-hexanone
Transport Hazard Class(es): 3 (Flammable Liquids)
Packing Group: III
Marine Pollutant: No
Special Precautions for Transport: Store upright, secure containers to prevent movement, keep away from sources of ignition during transit
Label Required: Flammable liquid
Regulatory References: US DOT, IATA, IMDG regulations apply
OSHA Status: Flammable, hazardous chemical under Hazard Communication Standard
TSCA Status: Listed in TSCA inventory
SARA Section 302/304: Not subject to reporting
SARA Section 313: Not listed as a toxic chemical
California Proposition 65: Not listed as a chemical known to cause cancer or reproductive toxicity
WHMIS Classification (Canada): B2 (Flammable liquid), D2B (Toxic materials)
Other State, National, or International Regulations: Subject to chemical safety assessment per REACH (EU), comply with workplace exposure guidelines
