Chemical Name: Diisopropylamine
Synonyms: N-isopropylpropan-2-amine; DIPA
CAS Number: 108-18-9
Molecular Formula: C6H15N
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Intended Use: Chemical manufacturing, solvent, intermediate in organic synthesis
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Classification (GHS): Flammable Liquid Category 2, Acute Toxicity (oral, dermal, inhalation) Category 4, Skin Corrosion Category 1B, Eye Damage Category 1, Specific Target Organ Toxicity — Single Exposure Category 3
Label Elements: Signal word – Danger; Hazard pictograms – Flame, Exclamation mark, Corrosive
Hazard Statements: Highly flammable liquid and vapor. Harmful if inhaled, swallowed or in contact with skin. Causes severe skin burns and eye damage. May cause respiratory irritation.
Precautionary Statements: Keep away from sparks, hot surfaces, open flames. Avoid breathing vapors or mist. Use with protective gloves, clothing, and eye/face protection. In case of incident, seek medical advice immediately.
Substance: Diisopropylamine
Concentration: Typically 98-100% by weight
Impurities/Stabilizing Additives: Trace water, secondary amine impurities below 1%
CAS Number: 108-18-9
EC Number: 203-558-5
General: Move person to fresh air. Remove contaminated clothing immediately.
Inhalation: Give oxygen if breathing is difficult. If not breathing, begin artificial respiration and get medical help right away.
Skin Contact: Flush skin with large amounts of water for at least 15 minutes. Remove exposed clothes and shoes. Seek medical advice.
Eye Contact: Rinse cautiously with water for several minutes (15 minutes minimum). Remove contact lenses if present. Obtain ophthalmologist evaluation.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly. Give water to drink if conscious. Contact poison control or a doctor.
Suitable Extinguishing Media: Use alcohol-resistant foam, dry chemical powder, or carbon dioxide. Water spray can be used for cooling containers, but direct water streams may spread fire.
Special Hazards: Vapors can travel to ignition sources. Burning produces toxic fumes including carbon monoxide, oxides of nitrogen.
Protective Equipment: Wear full bunker gear including self-contained breathing apparatus.
Specific Methods: Isolate hazard area. Use water fog to knock down vapors. Contain and collect run-off to prevent environmental contamination.
Personal Precautions: Evacuate unnecessary personnel. Ventilate area. Use proper PPE – chemical goggles, gloves, impervious suit, and respirator.
Environmental Precautions: Prevent spill from entering watercourses, drains, or soil.
Methods for Containment: Dike with sand or inert material. Neutralize using dilute acid solution.
Cleanup Procedure: Absorb with non-combustible material. Shovel into appropriate waste container. Wash spill area with water. Dispose in accordance with regulations.
Handling: Handle in tightly closed systems. Use spark-proof tools and explosion-proof equipment. Wash hands thoroughly after handling. Avoid contact with skin, eyes, and clothing.
Storage: Store in a cool, dry, well-ventilated area away from heat, direct sunlight, oxidizers and acids. Keep container tightly closed and properly labeled. Use corrosion-resistant containers. Ground and bond containers and equipment.
Incompatibilities: Strong oxidizers, acids, acid chlorides, acid anhydrides. Avoid heat, flame, and other sources of ignition.
Occupational Exposure Limits: ACGIH TLV: 5 ppm TWA, 10 ppm STEL (skin notation); OSHA PEL: 5 ppm TWA
Engineering Controls: Use local exhaust ventilation. Maintain eye washes and safety showers nearby.
Personal Protective Equipment: Wear butyl rubber or nitrile gloves. Use chemical goggles and face shield. Wear lab coat or chemical-resistant suit.
Respiratory Protection: Use NIOSH/MSHA approved respirators if risk of exposure to vapors, especially in confined spaces.
Hygiene Measures: Do not eat, drink, or smoke in work area. Remove contaminated clothing quickly.
Appearance: Clear, colorless to pale yellow liquid
Odor: Distinct ammonia-like odor
Odor Threshold: 0.13 ppm
Boiling Point: 84°C (183°F)
Melting Point: -60°C (-76°F)
Flash Point: 13°C (55°F) (closed cup)
Flammability: Highly flammable
Vapor Pressure: 78 mmHg at 20°C
Vapor Density: 3 (Air = 1)
Relative Density: 0.719 g/cm³
Solubility: Miscible with water, alcohols, ethers
Partition Coefficient (n-octanol/water): log Kow: 1.6
Autoignition Temperature: 410°C
Decomposition Temperature: Not established
Viscosity: Not measured
Chemical Stability: Stable under ordinary temperature and pressures in sealed containers
Possibility of Hazardous Reactions: Reacts violently with acids and oxidizing agents. Risk of fire and explosion in contact with strong oxidizers.
Conditions to Avoid: Heat, sparks, open flames, sources of ignition, electrostatic charge buildup
Incompatible Materials: Strong oxidizing agents, acids, acid anhydrides, acid chlorides
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, ammonia fumes
Routes of Exposure: Inhalation, ingestion, dermal, eye contact
Acute Toxicity: Oral LD50 (rat): 820 mg/kg; Dermal LD50 (rabbit): 800 mg/kg; Inhalation LC50 (rat, 4h): 7.18 mg/L
Skin Corrosion/Irritation: Severe skin burns
Serious Eye Damage/Irritation: Severe, risk of permanent injury
Respiratory Effects: May cause respiratory tract irritation
Chronic Effects: Prolonged or repeated exposure can cause dermatitis, sensitization. Central nervous system effects possible with high exposure.
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: Data not sufficient
Reproductive Toxicity: Data not sufficient
Toxicity to Aquatic Life: Fish LC50 (Pimephales promelas, 96h): 180 mg/L
Other Ecotoxicity Data: Daphnia EC50 (48h): 67 mg/L; Algae EC50 (72h): 43 mg/L
Persistence and Degradability: Readily biodegradable
Bioaccumulative Potential: Low potential; log Kow: 1.6
Mobility in Soil: High mobility; soluble and volatile
Other Adverse Effects: Causes increase in pH if released in large quantities. May be harmful to aquatic life in concentrated spills.
Disposal Methods: Dispose of contents and container at approved waste facility. Incineration preferred for larger amounts.
Container Disposal: Triple rinse, puncture, and remove label before recycling or disposal; ensure all residues removed.
RCRA Status: D001 (ignitable waste)
Precautions for Disposal: Do not dispose to sewer, waterways, or environment. Follow local, regional, and national regulations.
UN Number: UN1158
UN Proper Shipping Name: Diisopropylamine
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: II
Labels: Flammable Liquid, Corrosive
Marine Pollutant: No
Special Precautions: Keep containers upright and secure. Avoid heat sources and incompatibles during transport.
US Federal Regulations: Listed on TSCA Inventory. SARA Title III Sec. 302 (EHS): No; Sec. 311/312 Hazard Categories: Acute Health Hazard, Fire Hazard; Sec. 313: Not subject.
OSHA: Regulated hazardous chemical.
Canada (DSL/NDSL): Listed.
EU Regulations: REACH registered; CLP classified as Flammable, Corrosive, Harmful.
Other Regulations: Subject to workplace exposure monitoring and hazardous material transport rules worldwide.
