Substance Name: Diisopropylethylamine
Synonyms: DIPEA, Hünig's base, N,N-Diisopropylethylamine
CAS Number: 7087-68-5
Recommended Use: Laboratory chemical, used in organic synthesis as a base
Supplier: Refer to local supplier or distributor
Emergency Telephone: Refer to institutional emergency contact or chemical helpline
Address: Refer to the specific supplier or workplace documentation for chemical deliveries
GHS Classification: Flammable liquids (Category 3), Acute toxicity – Oral (Category 4), Acute toxicity – Dermal (Category 4), Skin irritation (Category 2), Eye irritation (Category 2A), Specific target organ toxicity – single exposure (Category 3)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor, harmful if swallowed or in contact with skin, causes skin and serious eye irritation, may cause drowsiness or dizziness; irritating to mucous membranes
Pictograms: Flame, Exclamation mark
Precautionary Statements: Avoid breathing vapors or mist, use only outdoors or in a well-ventilated area, wear protective gloves and eye protection, keep away from heat/sparks/open flames/hot surfaces
Chemical Name: N,N-Diisopropylethylamine
Chemical Formula: C8H19N
Molecular Weight: 129.25 g/mol
Concentration: 95-100%
Impurities: Trace impurities possible, refer to supplier certificate
General Advice: Move out of hazardous area, seek medical attention if symptoms persist
Inhalation: Remove to fresh air, keep comfortable for breathing, get medical support
Skin Contact: Take off contaminated clothing, wash exposed skin with plenty of soap and water
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing if needed, consult eye specialist
Ingestion: Rinse mouth thoroughly, do not induce vomiting, obtain medical attention immediately
Suitable Extinguishing Media: Dry chemical, CO2, alcohol-resistant foam, water spray
Unsuitable Media: Do not use direct water jets on burning liquid
Specific Hazards: Vapors can form explosive mixtures with air, risk of flashback, combustion generates toxic fumes such as nitrogen oxides and carbon oxides
Special Protective Equipment: Use self-contained breathing apparatus and protective suit for fire fighting
Additional Information: Cool containers with water spray to prevent pressure build-up, evacuate area in case of large spill
Personal Precautions: Evacuate unprotected personnel, avoid breathing vapors, ensure good ventilation, wear suitable protective equipment
Environmental Precautions: Prevent product from entering drains, soil, and surface water; inform environmental authorities if product reaches the environment
Methods for Containment: Absorb leaks with inert absorbent, keep away from sources of ignition
Methods for Cleaning Up: Scoop up spill with non-combustible material (vermiculite, sand), clean contaminated surface thoroughly
Disposal: Place in suitable chemical waste container for proper disposal, decontaminate spill area
Handling: Avoid skin and eye contact, avoid inhaling vapors, use only in well-ventilated areas, keep container tightly sealed when not in use, ground container and transfer equipment, use spark-proof tools
Storage: Keep in a cool, dry, well-ventilated area, store away from incompatible materials such as oxidizers, acids, and moisture, store in original or approved tightly-closed container, keep away from ignition sources
Special Considerations: Protect from sunlight, static discharge precautions needed, label containers clearly
Engineering Controls: Use laboratory fume hood, local exhaust ventilation, eyewash station and safety shower required in work area
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles or face shield, lab coat or apron, flame-resistant clothing in case of fire risk
Respiratory Protection: Use approved respirator if ventilation inadequate, especially for high concentrations
Exposure Limits: No established occupational exposure limits (consult local regulations for guidance)
Environmental Exposure: Avoid release into the environment, minimize vapor generation
Appearance: Colorless to pale yellow liquid
Odor: Ammonia-like, strong
Odor Threshold: Not specified in literature
pH: Basic, not applicable for pure liquid
Melting Point/Freezing Point: Below -40°C
Boiling Point: Around 127°C
Flash Point: 40°C (closed cup)
Evaporation Rate: Not specified
Flammability: Flammable liquid
Upper/Lower Flammability or Explosive Limits: Lower: 1.2 vol% / Upper: 6.6 vol% (approximate)
Vapor Pressure: 4.8 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: 0.742 at 20°C
Solubility: Slightly soluble in water, miscible with organic solvents
Partition coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Around 215°C
Decomposition Temperature: Not specified
Viscosity: Similar to other light amines
Reactivity: Reacts with oxidizing agents, acids, acid chlorides, halogens
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: May form explosive mixtures with air, reacts vigorously with strong acids or oxidants
Conditions to Avoid: Heat, sparks, flames, static discharge
Incompatible Materials: Acid chlorides, anhydrides, powerful oxidizers, strong acids
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, toxic vapors
Likely Routes of Exposure: Ingestion, inhalation, skin contact, eye contact
Acute Toxicity: LD50 Oral Rat ~830 mg/kg, LD50 Dermal Rabbit >2000 mg/kg
Skin Corrosion/Irritation: Causes moderate to severe irritation, prolonged exposure may result in chemical burns
Serious Eye Damage/Irritation: Causes irritation, potential for permanent eye injury
Respiratory or Skin Sensitization: Data not conclusive, avoid prolonged exposure
Germ Cell Mutagenicity: No data available
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, ACGIH, or OSHA
Reproductive Toxicity: No data available
Specific Target Organ Toxicity – Single Exposure: May cause drowsiness or dizziness
Specific Target Organ Toxicity – Repeated Exposure: No data
Aspiration Hazard: No data
Other Effects: Inhalation of vapor/mist can cause respiratory irritation, headaches, nausea
Ecotoxicity: Toxic to aquatic organisms based on similar aliphatic amines
Persistence and Degradability: Expected to biodegrade under aerobic conditions, but data limited
Bioaccumulative Potential: Potential for bioaccumulation exists, though low compared with aromatic amines
Mobility in Soil: Mobile in soils, may volatilize
Other Adverse Effects: Avoid release to the environment, product contributes to chemical oxygen demand, may cause local pH shift in water bodies
Disposal of Substance: Incinerate in licensed facility or dispose according to local/national regulations
Contaminated Packaging: Triple rinse, then offer for recycling or disposal; puncture and dispose as hazardous residue
Special Precautions: Label waste containers clearly, prevent accidental exposure during disposal
Disposal Restrictions: Do not discharge to environment, sewers, or waterways
UN Number: UN2734
Proper Shipping Name: Amines, liquid, corrosive, flammable, n.o.s. (contains Diisopropylethylamine)
Transport Hazard Class: 3 (Flammable liquid), 8 (Corrosive)
Packing Group: II
Labels: Flammable liquid, Corrosive
Environmental Hazards: Marine pollutant
Special Precautions for User: Follow transport security regulations, emergency response information sheet required onboard
International Transport Regulations: Complies with IMDG, IATA, ADR standards for hazardous chemicals
OSHA Status: Hazardous chemical as defined by Hazard Communication Standard
TSCA Status: Listed in US TSCA Inventory
EU Regulations: Registered under REACH; subject to restrictions for professional use
WHMIS Classification: B2 (Flammable Liquids), D2B (Toxic Materials), E (Corrosive Materials)
SARA Title III Section 313: Not listed
California Proposition 65: Chemical not listed
Other Regulations: National, state, and local regulations apply for sales, storage, and handling; safety training required for workers
