Product Name: Isobutylamine
Chemical Formula: C4H11N
CAS Number: 78-81-9
EC Number: 201-130-8
Synonyms: 2-Methyl-1-propanamine, 1-Amino-2-methylpropane
Recommended Use: Used as a chemical intermediate, solvent, corrosion inhibitor, and in laboratory research
Supplier Information: Manufacturer or supplier’s full contact information including address, phone number, emergency telephone number
Classification: Flammable liquid, Acute toxicity (oral, dermal, inhalation), Skin corrosion/irritation, Serious eye damage, Respiratory irritation
Signal Word: Danger
Hazard Statements: Highly flammable liquid and vapor, Toxic if swallowed, in contact with skin or if inhaled, Causes severe skin burns and eye damage, May cause respiratory irritation
Pictograms: Flame, Skull and crossbones, Corrosive, Exclamation mark
Precautionary Statements: Keep away from heat, sparks, open flames, and hot surfaces, Avoid breathing vapors or mist, Wear protective gloves, clothing, eyewear, and face protection, Wash hands thoroughly after handling, Use explosion-proof equipment
Emergency Overview: Clear, colorless liquid with strong ammonia-like odor, vapor may irritate eyes and respiratory system
Chemical Name: Isobutylamine
CAS Number: 78-81-9
Concentration: ≥99%
Impurities: Trace water or alcohols depending on storage and production method, typically less than 1%
General Advice: Move person to fresh air, remove contaminated clothing, seek immediate medical attention
Inhalation: Remove to fresh air, keep at rest, assist breathing if necessary, call for medical help
Skin Contact: Wash immediately with plenty of soap and water, remove contaminated clothing, seek medical attention for ongoing irritation
Eye Contact: Rinse carefully with water for 15 minutes, hold eyelids apart, remove contact lenses if present, continue rinsing, get medical help
Ingestion: Do not induce vomiting, rinse mouth, drink water if conscious, do not give anything by mouth if unconscious, seek immediate medical attention
Most Important Symptoms: Severe irritation, burns or pain in mouth, throat, stomach, eyes, possible respiratory distress if inhaled
Suitable Extinguishing Media: Dry chemical powder, CO2, foam, alcohol-resistant foam
Unsuitable Media: Do not use water jet, as it may spread the fire
Hazardous Combustion Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Special Protective Equipment for Firefighters: Full protective clothing, self-contained breathing apparatus
Fire and Explosion Hazards: Vapors can form explosive mixtures with air, ignition sources include heat, sparks, static electricity
Firefighting Instructions: Keep containers cool with water spray, fight fire from a safe distance, remove containers from fire area if safe to do so
Personal Precautions: Evacuate area, ventilate, avoid inhalation/skin contact, use recommended personal protective equipment
Environmental Precautions: Prevent entry into waterways, soil, drains, or sewers
Methods for Clean-Up: Contain spill with inert material, absorb with non-combustible material such as sand or earth, shovel up and transfer to suitable container for disposal, wash spill site with plenty of water
Cleanup Procedures: Ensure adequate ventilation, eliminate all ignition sources, use spark-proof tools
Handling: Work with chemical in well-ventilated area or use fume hood, avoid breathing vapors, prevent skin and eye contact, ground and bond containers during transfer, use explosion-proof electrical equipment
Storage: Store in tightly sealed containers, in a cool, dry, well-ventilated place away from sources of ignition, segregate from acids, oxidizers, and other incompatible materials, protect from moisture and direct sunlight
Special Precautions: Keep locked up, store separately from food and drink, label storage containers clearly
Exposure Limits: Consult local, national exposure guidelines (Occupational Safety and Health Administration (OSHA) or ACGIH for workplace limits; often TWA for isobutylamine not specifically established, recommend keeping below 5 ppm if possible)
Engineering Controls: Use local exhaust ventilation, explosion-proof equipment, safety showers, eyewash stations
Respiratory Protection: Use approved respirator for organic vapors if exposure levels are above recommended limits
Skin Protection: Butyl rubber or nitrile gloves, chemical-resistant clothing, lab coat
Eye Protection: Chemical safety goggles with side shields, face shield for splash protection
Hygiene Measures: Do not eat, drink, or smoke when handling this chemical, wash hands and face thoroughly after use
Appearance: Colorless liquid
Odor: Strong, amine-like, fishy
Odor Threshold: Detectable at very low concentrations (below 1 ppm)
pH: Strongly alkaline in solution
Melting Point: -68°C
Boiling Point: 68°C
Flash Point: -10°C (closed cup)
Evaporation Rate: Fast (higher than water)
Flammability: High
Explosive Limits: Lower 1.5%, Upper 11.4% (by volume in air)
Vapor Pressure: 220 mmHg at 20°C
Vapor Density: 2.1 (air = 1)
Density: 0.74 g/cm³ at 20°C
Solubility in Water: Miscible
Partition Coefficient (log Kow): 0.28
Auto-Ignition Temperature: 312°C
Decomposition Temperature: Not well-defined, decomposes at high temperatures
Viscosity: Low, like water
Chemical Stability: Stable under normal conditions, forms dangerous vapors at high temperatures
Possibility of Hazardous Reactions: Reacts exothermically with acids, oxidizing agents, halogens
Conditions to Avoid: Heat, sparks, open flames, static electricity, moisture, contact with incompatible materials
Incompatible Materials: Strong acids, acid chlorides, acid anhydrides, oxidizing agents, copper, copper alloys, aluminum
Hazardous Decomposition Products: Toxic nitrogen oxides, carbon monoxide, carbon dioxide, ammonia
Acute Toxicity: Causes severe burns to skin, eyes, respiratory tract; can be fatal if inhaled or ingested in large amounts
LD50 (Oral, Rat): Approximately 250 mg/kg
LD50 (Dermal, Rabbit): About 200 mg/kg
LC50 (Inhalation, Rat, 4 hr): 1.2 mg/L
Skin Corrosion/Irritation: Severe burns
Eye Damage/Irritation: Severely damages eyes, possible blindness
Respiratory Sensitization: Causes coughing, shortness of breath, risk of lung edema
Other Effects: Dizziness, headache, confusion, nausea possible after significant exposure; chronic exposure may damage liver or kidneys
Routes of Exposure: Inhalation, ingestion, skin/eye contact
Ecotoxicity: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence/Degradability: Biodegradable in water and soil over several days to weeks, but high concentrations may disrupt wastewater treatment
Bioaccumulation Potential: Low (log Kow around 0.28 suggests little expected accumulation)
Mobility in Soil: High mobility due to solubility in water
Other Adverse Effects: Raises pH in water bodies, can harm fish and plants, avoid discharge to the environment
Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations; consult with hazardous waste disposal specialist
Unused Product: May require incineration at licensed facility
Contaminated Packaging: Triple rinse, offer for recycling, do not reuse containers, follow container disposal regulations
Disposal of Spills: Absorb with inert material, place in chemical waste drum, do not wash down drain or release to the environment
UN Number: UN1224
Proper Shipping Name: Isobutylamine
Transport Hazard Class: 3 (Flammable liquid), 8 (Corrosive), Primary: 3, Subsidiary: 8
Packing Group: I (high danger)
Labeling Requirements: Flammable, Corrosive
Marine Pollutant: Not designated as marine pollutant, but take proper environmental precautions during transport
Special Precautions: Transport in tightly sealed, upright containers, keep away from incompatible materials and foodstuffs, follow all local and international regulations for flammable and corrosive substances
EPA Status: Listed as hazardous under CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act)
TSCA: Listed on the Toxic Substances Control Act inventory
SARA 313: Subject to reporting under SARA Title III, Section 313 as a toxic chemical
OSHA: Classified as hazardous; subject to OSHA workplace safety requirements
WHMIS (Canada): Controlled product, flammable and corrosive material
REACH (Europe): Registered; safety data available in compliance with REACH/CLP regulations
Other Regulations: Local, regional, and international regulations exist regarding use, storage, and disposal; obtain information from relevant authorities for compliance
