Chemical Name: Isopropylamine
Synonyms: 2-Aminopropane, Monoisopropylamine, MIPA
CAS Number: 75-31-0
Recommended Use: Chemical intermediate, solvent, corrosion inhibitor, pesticide formulation
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UN Number: 1221
GHS Classification: Flammable liquid (Category 2); Acute toxicity (Oral, Inhalation, Dermal, Category 3); Skin corrosion/irritation (Category 1B); Serious eye damage (Category 1)
Signal Word: Danger
Hazard Statements: Highly flammable liquid and vapor; Toxic if swallowed, inhaled, or in contact with skin; Causes severe skin burns and eye damage
Pictograms: Flame, Skull and crossbones, Corrosion
Potential Health Effects: Strong vapors cause respiratory irritation; Direct contact causes burns to skin and eyes; Ingestion and extensive inhalation may result in systemic toxicity and death; Chronic exposure affects liver and kidneys
Chemical: Isopropylamine
CAS Number: 75-31-0
Purity: 99% minimum
Impurities: Water, traces of other amines & hydrocarbons (less than 1%)
Stabilizers: None intentionally added
Inhalation: Move person to fresh air. Loosen tight clothing and monitor breathing. Seek medical advice immediately. Artificial respiration if breathing stops.
Skin Contact: Remove contaminated clothing. Rinse skin with plenty of running water for at least 15 minutes. Seek medical attention for burns or irritation.
Eye Contact: Flush eyes with water for a minimum of 20 minutes, lifting eyelids. Remove contact lenses if present and continue rinsing. Immediate medical follow-up is essential.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly with water if person is conscious. Get urgent medical help.
Symptoms of Exposure: Burns, coughing, shortness of breath, chest pain, nausea, dizziness, headache, tearing, and vision irritation.
Flammability: Highly flammable liquid and vapor
Suitable Extinguishing Media: Dry chemical, foam, CO2, water spray (use water spray to cool containers only; do not use direct water jet)
Fire & Explosion Hazards: Vapors form explosive mixtures with air; rapid pressure build-up if heated
Protective Equipment: Self-contained breathing apparatus (SCBA) and full body protective clothing
Hazardous Combustion Products: Nitrogen oxides, carbon monoxide, carbon dioxide, ammonia
Special Procedures: Evacuate area, contain run-off water, avoid inhalation of combustion gases
Personal Precautions: Wear splash-resistant goggles, chemical-resistant gloves and apron, boots, and suitable respiratory equipment. Keep unprotected people away.
Environmental Precautions: Prevent spillage from entering drains, surface water, or soil. Alert local authorities if product contaminates the environment.
Cleanup Procedures: Ventilate area. Absorb liquid with inert materials (sand, vermiculite), shovel into suitable chemical waste containers. Wash area with water after material removal. Dispose in accordance with local, state, and federal regulations.
Decontamination: Neutralize residue with dilute acid solution under controlled conditions
Handling: Only handle in well-ventilated areas with proper grounding and bonding of containers. Do not breathe vapors or come into contact with liquid. Avoid sources of ignition; use spark-proof tools. Use explosion-proof equipment.
Storage Conditions: Store in cool, dry, well-ventilated location away from heat, sparks, open flames, and oxidizing agents. Store in tightly closed containers. Segregate from acids, halogens, and strong oxidizers. Keep electrical fittings non-sparking.
Packaging: Use containers made of compatible material such as steel or HDPE lined drums
Incompatibilities: Strong acids, acid chlorides, acid anhydrides, oxidizing agents, halogens
Exposure Limits: OSHA PEL: 5 ppm (TWA); ACGIH TLV: 5 ppm (TWA); NIOSH REL: 5 ppm (TWA)
Engineering Controls: Use local exhaust ventilation, process enclosure, or other engineering methods to control airborne levels below recommended exposure limits
Personal Protective Equipment (PPE): Chemical-resistant gloves, goggles or face shield, flame-resistant clothing, boots, and suitable respiratory protection (air-purifying respirators or SCBA
Hygiene Measures: Wash hands and face thoroughly after handling. Remove contaminated clothing before entering eating areas. Do not eat, drink, or smoke in work area. Keep emergency shower and eye wash stations nearby
Physical State: Colorless liquid or gas at room temperature (liquid under pressure)
Odor: Strong, ammonia-like
Boiling Point: 32 – 33°C (89.6 – 91.4°F)
Melting Point: -95°C (-139°F)
Flash Point: -17°C (1.4°F) (closed cup)
Auto-ignition Temperature: 405°C (761°F)
Lower Explosion Limit: 1.7%
Upper Explosion Limit: 10.1%
Vapor Pressure: 398 mmHg (20°C)
Density: 0.693 g/cm³ (20°C)
Solubility: Miscible in water, ethanol, ether
pH (10% aqueous): 12.0 – 13.0
Viscosity: 0.4 mPa·s (20°C)
Chemical Stability: Stable under recommended storage and handling conditions.
Conditions to Avoid: Heat, flames, sparks, sources of static electricity, sunlight, high temperatures, moisture
Incompatible Materials: Strong acids, acid chlorides, acid anhydrides, oxidizers, halogens, copper, brass, bronze
Hazardous Decomposition: Nitrogen oxides, carbon oxides, ammonia, irritating and toxic fumes
Hazardous Reactions: Generates heat and toxic gas on reaction with acids, strong oxidizers, or halogenated hydrocarbons
Acute Toxicity: Oral LD50 (rat): 256 mg/kg; Inhalation LC50 (rat, 4h): 2998 ppm; Dermal LD50 (rabbit): 820 mg/kg
Corrosive Properties: Causes severe skin and eye burns; potential for permanent damage
Chronic Effects: Prolonged exposure causes liver, kidney, nervous system damage. Possible risk of dermatitis and respiratory sensitization with repeated contact
Symptoms: Burning, redness, blistering, tearing, blurred vision, coughing, headache, nausea, vomiting, dizziness, wheezing, chest tightness
Carcinogenicity: Not classified as carcinogenic (IARC, NTP, OSHA)
Mutagenicity: No evidence in standard tests
Reproductive Toxicity: No conclusive data, but not classified as a reproductive toxin
Target Organs: Respiratory system, skin, eyes, liver, kidneys
Ecotoxicity: Toxic to aquatic organisms. Fish (LC50, 96h): Lepomis macrochirus 168 mg/L; Daphnia (EC50, 48h): 320 mg/L
Degradability: Readily biodegradable in aquatic environment; rapid breakdown under aerobic conditions
Bioaccumulation: Low potential for bioaccumulation (log Kow = 0.09)
Mobility in Soil: High mobility; volatile from water and soil surfaces
Other Adverse Effects: Forms corrosive solutions in water, affects local pH, potential toxicity to plants and microorganisms at high concentrations
Waste Disposal Methods: Collect and transfer waste into clearly labeled, tightly sealed containers. Incinerate in an approved facility with afterburner and scrubber. Follow all local, state, and federal regulations for disposal.
Container Disposal: Triple rinse and puncture empty containers before recycling or disposal.
Contaminated Packaging: Handle as product waste; avoid environmental release
Special Precautions: Do not discharge into water courses, sewers, or public drains; do not landfill liquid residue
UN Number: 1221
UN Proper Shipping Name: Isopropylamine
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: I
Hazard Labels: Flammable liquid, Toxic substance
Marine Pollutant: No (but avoid release to environment)
Special Precautions: Transport in well-ventilated vehicles. Secure containers. Comply with all transport regulations for road, rail, sea, and air
TSCA Inventory: Listed
EU REACH Status: Registered
OSHA Hazard Communication: Covered
EPA SARA Title III: Section 302 (Extremely Hazardous Substance) – No; Section 313 (Toxic Chemicals) – Yes
WHMIS Classification (Canada): B2 (Flammable liquid), D1A, D2A (Very toxic)
Other International Regulations: Listed on Australian AICS, Canadian DSL, Japanese ENCS, China IECSC
Label Information: Corrosive, toxic, flammable signals required on all packaging and containers according to local classification
