Product Name: Tributylphosphine Oxide
Chemical Formula: C12H27OP
CAS Number: 7784-24-9
Synonyms: TBPO, Tributylphosphoryl oxide, Tributylphosphane oxide
Recommended Use: Chemical intermediate, Laboratory reagent
Supplier Information: Include authorized distribution channel’s contact details for emergency and routine questions
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation – Category 4); Eye Irritation – Category 2; Skin Irritation – Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed, Causes skin irritation, Causes serious eye irritation
Precautionary Statements: Wash exposed skin thoroughly after handling, Wear protective gloves and eye protection, Use only in well-ventilated areas, Avoid breathing dust or vapor
Pictograms: Exclamation mark
Other Hazards: May be harmful to aquatic life with long-lasting effects, Avoid release to the environment
Chemical Name: Tributylphosphine Oxide
Chemical Formula: C12H27OP
CAS Number: 7784-24-9
Content: >98% by weight
Impurities and Stabilizing Additives: Typically less than 2%. Further details depend on supplier.
Inhalation: Move affected person to fresh air, Keep at rest, Seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, Rinse skin immediately with soap and plenty of water, Seek medical attention for irritation
Eye Contact: Rinse cautiously with water for several minutes, Remove contact lenses if present and easy, Continue rinsing, Seek medical attention
Ingestion: Rinse mouth, Do not induce vomiting unless advised by medical personnel, Seek immediate medical attention
Suitable Extinguishing Media: Water spray, Alcohol-resistant foam, Dry chemical powder, Carbon dioxide
Specific Hazards: Emits toxic fumes including phosphine oxides and carbon oxides during combustion
Protective Equipment: Wear self-contained breathing apparatus and full protective clothing
Special Procedures: Move containers away from fire area if safe, Avoid getting water directly on product where risk of splatter exists
Personal Precautions: Use respiratory protection for ventilation, Prevent skin and eye contact with absorbent gloves and goggles
Environmental Precautions: Prevent runoff into sewers and waterways, Dike spill for collection and disposal
Methods for Clean-Up: Absorb spill with inert material such as sand or vermiculite, Collect in suitable container, Dispose following local regulation, Ventilate affected area thoroughly after cleanup
Handling: Avoid contact with skin, eyes, and clothing, Avoid breathing vapors or mists, Wash thoroughly after use, Use only in controlled ventilated area
Storage: Store in a cool, dry, well-ventilated place, Keep containers tightly closed and labeled, Keep away from heat, sparks, flame, and incompatible materials such as strong oxidizers
Incompatible Materials: Strong oxidants, Acids, Bases
Occupational Exposure Limits: No official exposure limits established, Follow general chemical best practices
Engineering Controls: Use fume hood or equivalent exhaust ventilation, Ensure eyewash stations and safety showers remain accessible
Personal Protection Equipment (PPE): Protective gloves (nitrile or neoprene), Safety goggles or face shield, Lab coat or chemical resistant clothing, Respiratory protection if airborne levels are significant
Appearance: Clear to yellowish oily liquid
Odor: Neutral to faint odor
Odor Threshold: Data not available
pH: Not applicable
Melting Point/Freezing Point: -59 °C
Boiling Point: 344 °C
Flash Point: 167 °C (COC)
Evaporation Rate: Data not available
Flammability: Not easily flammable
Vapor Pressure: <0.01 mmHg at 25 °C
Vapor Density: Heavier than air
Relative Density: 0.97 g/cm³
Solubility: Insoluble in water, Miscible with many organic solvents
Partition Coefficient (n-octanol/water): Data not available
Auto-Ignition Temperature: Data not available
Decomposition Temperature: Data not available
Viscosity: Data not available
Chemical Stability: Stable under normal storage and handling conditions
Reactivity: No hazardous reactions under normal conditions
Conditions to Avoid: Excessive heat, Open flames, Incompatible chemical contact
Incompatible Materials: Strong oxidizers, Acids, Bases
Hazardous Decomposition Products: Phosphine oxides, Carbon oxides may develop under combustion or extreme thermal decomposition
Likely Routes of Exposure: Inhalation, Skin, Eye, Ingestion
Acute Toxicity: Animal studies indicate moderate oral and dermal toxicity. Oral LD50 (rat): ~2,300 mg/kg.
Skin Corrosion/Irritation: Irritating to skin, May cause dryness or cracking
Serious Eye Damage/Irritation: Causes eye irritation
Respiratory Sensitization: Not classified based on available data
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA, or ACGIH
Repeated Dose Toxicity: Information lacking, Prolonged exposure could enhance target organ effects
Other Effects: No evidence for reproductive or mutagenic effects from available research
Ecotoxicity: Harmful to aquatic organisms, May cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Limited ready biodegradability, Likely to persist in environment
Bioaccumulative Potential: Potential for bioaccumulation remains moderate due to hydrophobic nature
Mobility in Soil: Low water solubility means likely adsorption to organic matter
Other Adverse Effects: Prevent release to natural water bodies and soil to reduce environmental impact
Waste Treatment Methods: Chemical waste specialists should handle disposal, Incineration under controlled conditions in accordance with local regulations
Contaminated Packaging: Triple rinse containers before disposal, Dispose containers as hazardous waste
Additional Recommendations: Do not pour into drains, Consider professional waste contractors for bulk volumes
UN Number: Not classified under UN recommendations for transport
UN Proper Shipping Name: Not regulated for transport under ADR, IMDG, IATA
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Environmental Hazards: Prevent release during transport
Special Precautions for User: Transport in secure and labeled containers, Ensure spill kits and PPE are available during transfer operations
TSCA Listing: Listed or effectively exempt
Inventory Status: Listed in EINECS/ELINCS, DSL/NDSL, AICS
OSHA Status: Not specifically regulated as a hazardous chemical
SARA Title III: Not subject to Section 302 or 313 reporting
Clean Water Act: Not listed
California Proposition 65: Not listed as a substance known to cause cancer, birth defects, or other reproductive harm
Other State Regulations: Subject to chemical reporting requirements per local jurisdiction
Additional Legal Requirements: Workplace labeling and training still required according to OSHA HazCom Standard and aligned GHS criteria
