Product Name: Triisobutylphosphine
Chemical Formula: C12H27P
Synonyms: Tributylisopropylphosphine, TIBP
CAS Number: 998-30-1
Recommended Use: Research, chemical synthesis, catalyst manufacturing
Supplier Details: Manufacturer or distributor contact information, including emergency phone number
UN Number: 3082 (for transport as a hazardous substance)
GHS Classification: Flammable liquid (Category 3), Acute toxicity (oral, Category 3), Skin irritation (Category 2), Serious eye irritation (Category 2A), Aquatic chronic hazard (Category 2)
Signal Word: Danger
Hazard Statements: Harmful if swallowed. Causes skin and eye irritation. Flammable liquid and vapor. Toxic to aquatic life with long lasting effects.
Precautionary Statements: Keep away from heat, open flames, and hot surfaces. Avoid breathing vapor or mist. Wash exposed skin thoroughly after handling. Avoid release to the environment.
Pictograms: Flame, Exclamation Mark, Environment
Chemical Name: Triisobutylphosphine
Concentration: >98% (technical grade)
Impurities: Traces of diisobutylphosphine, tributylphosphine, and unidentified organophosphorus compounds (less than 2%)
CAS Number: 998-30-1
EC Number: 213-670-4
Inhalation: Move exposed person to fresh air. Seek medical attention if respiratory symptoms appear or persist. If breathing stops, give artificial respiration.
Skin Contact: Remove contaminated clothing. Rinse skin thoroughly with water and soap for several minutes. Seek medical attention for persistent irritation or burns.
Eye Contact: Rinse cautiously with plenty of water for at least 15 minutes, holding eyelids open. Remove contact lenses if present. Get immediate medical attention if irritation persists.
Ingestion: Do not induce vomiting. Rinse mouth with water. Call a doctor or poison control center immediately. Never give anything by mouth to an unconscious person.
Extinguishing Media: Use dry chemical, foam, or carbon dioxide. Do not use water directly on chemical fire.
Special Hazards: Combustion releases toxic phosphorus oxides and hydrocarbons. Flammable vapors may form explosive mixtures with air.
Protective Equipment: Firefighters require full protective gear and self-contained breathing apparatus.
Firefighting Advice: Evacuate area. Cool containers with water spray from a safe distance to avoid pressure build-up and possible explosions.
Personal Precautions: Isolate area. Keep unnecessary or untrained persons away. Prevent skin and eye contact.
Protective Equipment: Wear protective gloves, goggles, chemical-resistant clothing, suitable respiratory protection.
Spill Cleanup: Absorb with inert materials like sand or diatomaceous earth. Collect and place in suitable containers for disposal. Clean spill area thoroughly.
Environmental Precautions: Prevent entry into waterways, drains, or soil. Notify local authorities if large spills occur.
Handling Practices: Work in well-ventilated spaces. Prevent static discharge. Ground and bond containers when transferring liquids. Use spark-proof tools.
Safe Storage: Store containers tightly closed in a cool, dry, well-ventilated location away from sources of ignition or open flames. Store separately from oxidizers, acids, or incompatible substances.
Storage Temperature: Recommended ambient temperature, protect from heat.
Incompatible Materials: Strong oxidizing agents, acids, halogens.
Packaging Materials: Use corrosion-resistant or polyethylene-lined drum.
Occupational Exposure Limits: No specific OSHA, NIOSH, or ACGIH exposure limits. Use strict industrial hygiene measures.
Engineering Controls: Use local exhaust ventilation, explosion-proof equipment, and fume hoods.
Personal Protection Equipment (PPE): Wear protective gloves (nitrile or neoprene), safety goggles, chemical-resistant lab coat or apron, and appropriate respirator in case of vapor generation.
Hygiene Practices: Wash hands and exposed skin thoroughly after handling. Avoid eating, drinking, or smoking in work areas. Remove contaminated clothing before entering public spaces.
Physical State: Liquid
Appearance: Colorless to pale straw-yellow
Odor: Pungent, disagreeable, “rotten fish” smell
Odor Threshold: Detectable at low concentrations
pH: Not applicable (non-aqueous)
Melting Point: -80 °C
Boiling Point: 181–185 °C
Flash Point: 43 °C (closed cup)
Flammability: Flammable
Vapor Pressure: 0.4 mmHg at 20 °C
Vapor Density: Heavier than air
Relative Density: 0.834 g/cm³ at 20 °C
Solubility: Insoluble in water; soluble in organic solvents (ethanol, ether, hexane)
Partition Coefficient (log Kow): Approx. 5.77
Auto-Ignition Temperature: 260 °C
Decomposition Temperature: Not established
Viscosity: Not measured
Chemical Stability: Stable under recommended storage conditions—sensitive to air and moisture.
Hazardous Reactions: Reacts vigorously with strong oxidizers, acids, halogens.
Polymerization: No hazardous polymerization expected.
Decomposition Products: Phosphine oxides, carbon monoxide, carbon dioxide, and hydrocarbons formed on thermal decomposition.
Conditions to Avoid: Exposure to heat, spark, flame, air, and water.
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Acute Toxicity: Oral LD50 (rat): 220 mg/kg. Inhalation: Symptoms include headaches, dizziness, coughing, respiratory discomfort, narcosis at high concentrations.
Skin Corrosion/Irritation: Irritant, may cause redness, pain, and burns with prolonged exposure.
Serious Eye Damage/Irritation: Moderate to severe irritation, lacrimation.
Respiratory Sensitization: Not established.
Germ Cell Mutagenicity: Not classified.
Carcinogenicity: No data available, not listed as carcinogen by NTP, IARC, or OSHA.
Reproductive Toxicity: Not tested.
Repeated Dose Toxicity: Not determined for chronic exposure.
Eco-toxicity: Toxic to aquatic life. May cause long-lasting adverse effects in aquatic environments.
Predicted Environmental Fate: Does not readily biodegrade. High potential for bioaccumulation due to lipophilicity.
Mobility in Soil: Limited mobility, adsorbs to soil particulate matter.
Persistence: Stable, not expected to degrade quickly.
Other Adverse Effects: Avoid entry to water bodies and sewers; potential risk to aquatic organisms.
Waste Disposal: Incinerate under controlled conditions by licensed chemical waste contractors. Do not dispose in landfill or municipal wastewater.
Contaminated Packaging: Triple-rinse then puncture and dispose as hazardous waste.
Environmental Precautions: Do not allow to contaminate soil, surface water, or groundwater.
Local Regulations: Disposal must comply with local, regional, and national environmental regulations.
UN Number: 3082
UN Proper Shipping Name: Environmentally hazardous substance, liquid, n.o.s. (Triisobutylphosphine)
Transport Hazard Class: 9 (Miscellaneous dangerous substances and articles)
Packing Group: III
Marine Pollutant: Yes
Transport Labels: Miscellaneous hazard, Environment
Special Transport Precautions: Secure tightly; avoid extreme temperatures and impacts during transit.
TSCA Status: Listed in U.S. Toxic Substances Control Act Inventory
EU Regulations: REACH registration required.
OSHA Hazard Communication: Meets criteria for hazardous chemical.
SARA Title III: Not listed under Section 302 or 313
California Proposition 65: Not known to contain chemicals subject to warning.
Other National or International Regulations: Subject to workplace safety, fire, environmental, and transportation regulations under relevant authorities.
