Product Name: Trioctylamine
Chemical Formula: C24H51N
CAS Registry Number: 1116-76-3
Synonyms: N,N-Dioctyloctanamine, TOA
Recommended Uses: Extraction solvent, phase transfer agent, chemical synthesis intermediate
Supplier Contact: Manufacturer or distributor, contact details vary by location
Emergency Contact: Chemtrec 1-800-424-9300 or local emergency services
UN Number: Not classified under UN hazardous chemicals
GHS Classification: Skin irritation (Category 2), Eye irritation (Category 2A), Aquatic chronic hazard (Category 2)
Pictograms: Exclamation mark, Environment
Signal Word: Warning
Hazard Statements: Causes skin irritation, causes serious eye irritation, may cause long-lasting harmful effects to aquatic life
Precautionary Statements: Wear protective gloves and eye protection, avoid release to the environment, wash hands thoroughly after handling, store securely
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Health Effects: Irritation of skin and eyes, respiratory effects possible
Environmental Hazards: Toxic to aquatic organisms, risk of long-term effects in the environment
Chemical Name: Trioctylamine
CAS Registry Number: 1116-76-3
Molecular Weight: 353.68 g/mol
Purity: >98% by weight
Impurities: Minor amounts of secondary amines, octyl alcohols possible depending on production
Stabilizers: None typically present
Additives: None added
Inhalation: Remove to fresh air, keep at rest, seek medical advice if symptoms persist
Skin Contact: Wash thoroughly with soap and water for at least 15 minutes, remove contaminated clothing
Eye Contact: Rinse immediately with plenty of water for 15 minutes, lift eyelids occasionally, seek medical attention
Ingestion: Rinse mouth, seek immediate medical attention, do not induce vomiting unless directed by a healthcare provider
Notes to Physician: Treat symptomatically, consider risk of aspiration and chemical irritation
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Extinguishing Media: High-pressure water jets
Specific Hazards: Can emit nitrogen oxides and toxic fumes under fire conditions; combustible but not highly flammable
Protective Equipment: Self-contained breathing apparatus, full protective gear
Special Procedures: Cool exposed containers with water, avoid inhaling combustion fumes
Personal Precautions: Wear gloves, eye protection, use good ventilation, prevent skin and eye exposure
Environmental Precautions: Prevent spillage from entering drains, sewers, or waterways
Method for Clean-Up: Absorb with inert material like sand or earth, place in suitable labeled containers for disposal, ventilate area
Emergency Procedures: Isolate area, keep unnecessary personnel away
Precautions for Safe Handling: Handle with care, avoid contact with eyes, skin, and clothing, always use in well-ventilated spaces, never eat or drink near the material
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing and wash before reuse
Storage Conditions: Keep tightly closed in a cool, dry, well-ventilated area away from incompatible substances such as acids and oxidizers
Container Requirements: Store in corrosion-resistant, clearly labeled containers
Incompatibilities: Strong oxidizers, acids, alkalis
Exposure Limits: No occupational exposure limits established for this substance
Engineering Controls: Use local exhaust or general ventilation to maintain exposure levels below recommended limits
Personal Protective Equipment: Chemical-resistant gloves (nitrile recommended), safety goggles, protective clothing, respiratory protection if vapors or aerosols formed
Environmental Controls: Use spill control measures to prevent environmental contamination
Hygiene Considerations: Change work clothes regularly, avoid consuming food or drink near operational areas
Appearance: Clear to pale yellow viscous liquid
Odor: Amine-like, unpleasant
pH: Not applicable (non-aqueous)
Melting Point: -34°C
Boiling Point: 365–370°C
Flash Point: 170°C (closed cup)
Evaporation Rate: Slow
Flammability: Not easily ignitable, forms combustible mixtures at high temperatures
Vapor Pressure: <0.01 mmHg at 20°C
Relative Density: 0.82–0.83 g/cm³ at 20°C
Solubility: Insoluble in water, soluble in organic solvents (alcohols, ethers, hydrocarbons)
Viscosity: High
Auto-Ignition Temperature: >250°C
Decomposition Temperature: Above 250°C
Partition Coefficient (n-octanol/water): >4
Chemical Stability: Stable under normal handling and storage conditions
Thermal Decomposition: Degrades on heating producing toxic fumes including nitrogen oxides
Materials to Avoid: Oxidizers, acids, acid chlorides - violent reactions possible
Hazardous Polymerization: Does not occur
Conditions to Avoid: Prolonged exposure to air, heat, ignition sources
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, volatile organic compounds
Acute Toxicity: LD50 oral (rat): >2000 mg/kg, relatively low acute toxicity
Skin Corrosion/Irritation: Known to irritate skin on prolonged or repeated exposure
Eye Damage/Irritation: Causes eye redness and discomfort
Respiratory or Skin Sensitization: No data for TRIOA, other trialkylamines have produced mild reactions
Long-Term Exposure: Chronic contact may cause dermatitis or eye injury
Ingestion Effects: Nausea, gastrointestinal upset if swallowed
Carcinogenicity: No evidence of carcinogenicity in animals or humans
Mutagenicity: No relevant studies indicating mutagenic or genotoxic effects
Specific Target Organ Toxicity: No evidence of single or repeated exposure effects
Ecotoxicity: Harmful to aquatic organisms; possible long-lasting effects
Mobility in Soil: Adsorbs to soil particles due to hydrophobic nature
Persistence/Degradability: Degrades slowly in environment; some biodegradation possible
Bioaccumulation: High potential for bioaccumulation in aquatic species given high log Pow
Aquatic Toxicity: LC50 (Fish, 96h): <10 mg/L, EC50 (Daphnia, 48h): <10 mg/L
Other Harmful Effects: May cause disruption to local terrestrial and aquatic environments if spilled
Waste Treatment Methods: Dispose of by incineration in approved facility or in accordance with local hazardous waste regulations
Contaminated Packaging: Offer rinsed containers for recycling or disposal as hazardous waste
Disposal Prohibitions: Do not pour into drains, watercourses, or soil
Regulatory Compliance: Consult national and local regulations, contact licensed disposal company
Precautions for Disposal: Use appropriate personal protective equipment and avoid environmental contamination
UN Number: Not classified as dangerous for road or sea transport under IMDG/IATA/ADR
Transport Hazard Classes: Not regulated as a hazardous material under current criteria
Packing Group: Not applicable
Environmental Hazards: Not classified as marine pollutant, but harmful to the environment if released
Special Precautions: Prevent leakage, use secure containers, label clearly
Regulatory Reference: Check with local transport authorities for national guidelines
Chemical Inventory Status: Listed in TSCA, EINECS, DSL/NDSL and other major inventories
Safety, Health and Environmental Regulations: Subject to general workplace safety rules requiring risk assessments and protective measures
Hazard Communication: GHS labels and Safety Data Sheets required in all handling and storage areas
Specific Restrictions: Not subject to specific restrictions under REACH or US OSHA, but general duty to prevent human and environmental exposure applies
Other Requirements: Annual reporting may apply under local emergency planning laws, record keeping of storage and disposal required
