Product Name: Trioctylphosphine
Chemical Formula: C24H51P
CAS Number: 4731-53-7
Recommended Use: Synthesis of organometallic compounds, nanomaterials research, laboratory chemical
Manufacturer: Chemical suppliers specializing in organophosphorus reagents
Emergency Contact: Refer to supplier label or regional poison information center
SDS Number: Provided by supplier per shipment
Synonyms: Phosphine, trioctyl-
Molecular Weight: 370.63 g/mol
Address: As listed on product documentation from supplier
Phone Number: Included with corresponding shipment paperwork
Classification: Flammable liquids, Acute toxicity (oral), Acute aquatic toxicity
GHS Label: Flame, Skull and Crossbones, Environment
Signal Word: Danger
Hazard Statements: Highly flammable liquid and vapor; Harmful if swallowed; Toxic to aquatic life
Precautionary Statements: Avoid breathing dust/fumes/gas/mist/vapors; Keep away from heat/sparks/open flames; Use explosion-proof equipment; Wear protective gloves/eye protection
Route of Exposure: Inhalation, skin contact, ingestion, eye contact
Target Organs: Respiratory system, digestive tract, skin, eyes
Potential Health Effects: Causes skin and eye irritation, respiratory discomfort, may cause dizziness or nausea on inhalation, ingestion can cause gastrointestinal disturbance
Environmental Risks: Harmful to aquatic organisms, may cause long-term adverse effects in aquatic environments
NFPA Ratings: Health: 2, Flammability: 3, Instability: 1
Chemical Name: Trioctylphosphine
CAS Number: 4731-53-7
Concentration: >99%
Impurities: Typically contains trace amounts of dioctylphosphine and other higher phosphines; minimal impurity profile required for high-purity applications
Stabilizing Additives: None present in pure product
Mixture Components: Not a mixture; substance is a pure compound
Relevant Decomposition Products: Phosphine oxides under prolonged exposure to air or strong oxidizers
Other Identifiers: None noted for general laboratory use
Inhalation: Move person to fresh air, keep at rest in position comfortable for breathing, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing immediately, flush skin with plenty of soap and water for at least 15 minutes, obtain medical attention for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, consult medical professional promptly
Ingestion: Rinse mouth thoroughly, do not induce vomiting, never give anything by mouth to an unconscious person, seek immediate medical help
Symptoms of Exposure: Respiratory discomfort, headache, dizziness, skin redness or burns, eye stinging or watering, abdominal pain if ingested
Advice for Medical Staff: Provide symptomatic treatment, monitor respiratory and cardiac function, treat chemical burns according to established protocols
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, sand
Unsuitable Media: Water jets may spread fire; avoid direct water stream
Special Hazards: May form flammable vapors heavier than air which travel along surfaces; combustion can release toxic phosphorus oxides and hydrocarbons
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear, avoid inhaling combustion products
Firefighting Procedures: Cool fire-exposed containers with water spray, remove sources of ignition, contain runoff to prevent environmental contamination
Explosion Risk: Vapor-air mixtures can explode if ignited in confined spaces; ventilate area after fire suppression
Other Notes: Keep containers tightly closed; evacuate personnel not involved in fire response
Personal Precautions: Evacuate area of unprotected personnel, ventilate, eliminate all sources of ignition, avoid inhalation or contact with skin and eyes
Environmental Precautions: Prevent entry into waterways, drains, soil; notify authorities of significant releases
Spill Cleanup Methods: Absorb liquid spill with inert non-combustible material such as sand or vermiculite, scoop into suitable chemical waste container, label for disposal
Decontamination Procedures: Wash spill area with water and detergent after collection, ventilate thoroughly
Protective Measures: Use personal protective equipment including gloves, splash goggles, lab coat or chemical apron, properly rated respirator if airborne concentrations are high
Disposal of Cleanup Materials: Place used absorbents in sealed containers for licensed hazardous waste handling
Handling Precautions: Use only in chemical fume hood or well-ventilated workspace, keep away from heat and open flames, ground containers during transfer, avoid static discharge
Personal Protection: Wear gloves resistant to organophosphorus chemicals (nitrile recommended), safety goggles or face shield, flame-resistant lab coat
Hygiene Practices: Wash hands thoroughly after handling; avoid eating, drinking, or smoking in working area
Storage Conditions: Keep containers tightly sealed, store in cool, dry, well-ventilated area away from direct sunlight and incompatibles like strong oxidizers; recommended storage temperature below 25°C
Container Materials: Store in glass or compatible plastic, avoid reactive metals
Segregation: Separate from acids, bases, and oxidizing materials to prevent dangerous reactions
Storage Limits: Check local regulations regarding flammable liquids; observe maximum quantity thresholds in labs and warehouses
Exposure Limits: No specific occupational exposure limits set for trioctylphosphine; general organic phosphorus exposure limits may apply
Engineering Controls: Local exhaust ventilation, fume hood, explosion-proof electrical installations in storage and transfer areas
Personal Protective Equipment: Chemical-resistant gloves (nitrile), safety goggles, lab coat or apron, closed shoes, face shield for splash risk
Respiratory Protection: Use certified respirator if risk of vapor release above recommended safe levels; fit-testing and filter selection governed by risk assessment
Environmental Protection: Procedures and barriers to prevent accidental release to sewer or natural water
Monitoring: Workplace air monitoring for phosphorus compounds in high-use areas, periodic review of PPE effectiveness, medical surveillance for chronic exposure risks
Appearance: Colorless to very pale yellow, oily liquid
Odor: Mild, characteristic, slightly fishy
Odor Threshold: Not reliably established
Boiling Point: Approximately 155 - 160°C at 8 mmHg
Melting Point: Below -60°C
Relative Density: 0.825-0.840 g/cm³ at 25°C
Solubility: Insoluble in water; soluble in most non-polar organic solvents such as hexane, toluene, and ethers
Vapor Pressure: Estimated < 0.2 mmHg at 20°C
Vapor Density: Heavier than air
pH: Not applicable (non-aqueous, non-ionizing)
Partition Coefficient (n-octanol/water): Log Kow estimated >7
Flash Point: 73°C (closed cup, approximate)
Auto-ignition Temperature: Not precisely determined; exercise typical caution for low-flash organophosphines
Evaporation Rate: Slow, based on high molecular weight and low vapor pressure
Decomposition Temperature: Not reliably established; begins to oxidize in presence of air at elevated temperature
Chemical Stability: Stable under inert gas and recommended storage conditions
Reactivity: May react strongly with oxidizing agents yielding hazardous products
Hazardous Reactions: Phosphorus oxides and organic phosphorus acid derivatives can form if mixed with strong oxidizers or upon prolonged exposure to air
Conditions to Avoid: Exposure to air, heat, ignition sources, strong bases or acids
Incompatible Materials: Oxidizers such as hydrogen peroxide, nitric acid, perchlorates; strong acids, certain metals
Hazardous Decomposition Products: Toxic phosphorus oxides, phosphine, octyl alcohols, hydrocarbons
Polymerization: Not known to polymerize under normal use
Acute Toxicity: Estimated LD50 (oral, rat): >1000 mg/kg; moderate acute toxicity
Skin Corrosion/Irritation: Can cause mild to moderate skin irritation on contact; redness, dryness, possible burns at higher exposures
Eye Damage: Causes irritation and tearing; possible transient injury on direct exposure
Respiratory Effects: May irritate nasal and respiratory tract if vapors inhaled; heavy or prolonged exposure could cause central nervous system depression
Chronic Exposure: Limited data; prolonged skin contact may cause defatting, dermatitis, or sensitization; avoid repeated unprotected exposure
Symptoms of Overexposure: Headache, dizziness, nausea, respiratory discomfort, gastric pain if ingested
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Mutagenicity/Germ Cell Effects: No data in published literature
Reproductive Toxicity: No evidence of reproductive effects at standard laboratory exposures
Target Organ Summary: Liver, skin, respiratory tract
Ecotoxicity: Toxic to aquatic organisms; high log Kow indicates potential for bioaccumulation
Aquatic Hazard: Adverse impact on fish and invertebrates at low concentrations
Persistence and Degradability: Likely persists in environment; slow biodegradation rate anticipated in natural waters
Bioaccumulation Potential: High due to large molecular weight and hydrophobic structure
Soil Mobility: Expected low mobility owing to insolubility in water and strong affinity for organic matter
Other Adverse Effects: No specific data for ozone depletion or photochemical smog; treat spills with care to prevent environmental contamination
Regulatory Notes: Follow protocols for substances harmful to aquatic life in chemical management plans
Waste Treatment Methods: Collect residues and contaminated packaging for disposal at licensed hazardous waste facility
Incineration: Suitable for complete destruction, only in chemical incinerators equipped with scrubber and afterburner
Container Disposal: Rinse thoroughly, triple-wash with compatible solvent, then dispose as hazardous waste
Region-specific Disposal: Follow local, national, and international laws governing chemical waste
Waste Codes: Assign according to local and US EPA hazardous waste codes for organic phosphorus compounds
Precautions: Do not allow undiluted material or large quantities to reach groundwater, waterways, or sewage systems
Packaging: Use tightly sealed, leak-proof, corrosion-resistant containers for storage and transport to disposal site
UN Number: 1993 (Flammable liquid, n.o.s. [Trioctylphosphine])
Shipping Name: Flammable liquid, n.o.s. (trioctylphosphine solution, if diluted)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Environmental Hazard: Marine pollutant—label and report accordingly
Transport Labels: Flammable liquid, environmental hazard pictogram
Special Transport Precautions: Store away from oxidizers, acids, or food cargo; keep container upright and secure
Road/Rail (ADR/RID): Provisions for flammable liquids and aquatic hazards apply
Air (ICAO/IATA): Check carrier policy for organic phosphorus compounds
Sea (IMDG): Marine pollutant requirements apply; stow away from incompatible materials
EU Regulations: Classified under REACH as hazardous; requires registration for import and manufacture; subject to Restrictions on Marketing and Use for hazardous organic phosphorus compounds
US Regulations: TSCA listed; SARA Title III Sections 311/312 hazardous categories include acute/flammable; not specifically listed under CERCLA or RCRA, consult for updates
Canada: DSL/NDSL status: Check with Canadian registries; WHMIS classification as flammable and toxic
Other Global Listings: Consult Australia AICS, Japan ENCS, China IECSC, Korea KECL for compliance before importing or manufacturing
Labeling Requirements: GHS-compliant pictograms and signal words; provide hazard, precaution, and first aid statements
Worker Safety Rules: Safety training required, maintain access to SDS, use of personal protective equipment under Local Occupational Safety and Health guidelines
Updates and Amendments: Monitor regulatory changes; maintain record of use, storage, and incidents as required by workplace safety plans
