Product Name: Tripropylamine
Synonyms: TPA, N,N-Dipropyl-1-propanamine
Chemical Formula: C9H21N
CAS Number: 140-70-3
Manufacturer: Refer to the container label or purchase documentation
Recommended Use: Intermediate in chemical synthesis, solvent, laboratory use
Emergency Contact: Refer to your workplace safety officer or call emergency services
GHS Classification: Flammable liquids (Category 3), Acute toxicity (Category 4, oral, dermal), Skin corrosion/irritation (Category 2), Serious Eye Damage/Irritation (Category 2A), Specific target organ toxicity - single exposure (Category 3)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor, Harmful if swallowed, Causes skin irritation, Causes serious eye irritation, May cause respiratory irritation
Precautionary Statements: Keep away from heat/sparks/open flames. No smoking. Avoid breathing vapors. Wear protective gloves and eye protection. Wash hands thoroughly after handling.
Pictograms: Exclamation mark, Flame
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Potential Health Effects: Irritation to mucous membranes, headache, dizziness, nausea, in severe overexposure possible central nervous system depression
Chemical Name: Tripropylamine
Concentration: ≥99%
CAS Number: 140-70-3
Impurities: May contain trace amounts of dipropylamine or other secondary amines arising from synthesis
Inhalation: Move to fresh air. If breathing becomes difficult, provide oxygen or artificial respiration. Seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing and rinse skin immediately with plenty of water. Wash with soap and water. Get medical attention if irritation continues.
Eye Contact: Immediately flush eyes with copious amounts of water for at least 15 minutes, lifting upper and lower eyelids. Remove contact lenses if present and easy to do. Get prompt medical attention.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly with water, then seek medical attention. Never give anything by mouth to an unconscious person.
Most Important Symptoms/Effects: Burning sensation, irritation of skin, eyes, and respiratory tract, headache, drowsiness, and nausea with large exposures.
Notes to Physician: Treat symptomatically and provide supportive care.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, alcohol-resistant foam
Unsuitable Extinguishing Media: Do not use water jet. Water can spread fire.
Specific Hazards: Vapors may travel to source of ignition and flash back. Thermal decomposition can produce carbon monoxide, carbon dioxide, nitrogen oxides, and toxic fumes.
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective gear. Cool containers exposed to fire with water spray.
Special Procedures: Avoid inhalation of combustion products. Evacuate area and fight fire from a safe distance.
Personal Precautions: Evacuate spill area. Keep unprotected personnel away. Provide adequate ventilation. Eliminate all ignition sources.
Environmental Precautions: Prevent material from entering drains, waterways, or soil. Notify local authorities if significant leaks or spills reach the environment.
Spill Cleanup: Wear suitable protective clothing, gloves, and eye/face protection. Absorb with inert material (sand, diatomite, earth), transfer to a chemical waste container. Wash spill area with water after material pick-up. Dispose of according to regulatory requirements.
Methods for Containment: Dike and contain spill with non-combustible material. Minimize vapor generation.
Safe Handling: Use only in a well-ventilated area. Avoid contact with eyes, skin, and clothing. Do not breathe vapors or mists. Ground and bond containers during transfer.
Storage Conditions: Keep tightly closed in a cool, dry, well-ventilated area away from heat and sources of ignition. Protect from moisture and incompatible materials like strong oxidizers and acids. Keep away from food and drink.
Special Requirements: Use explosion-proof equipment. Store in original container. Keep container upright to prevent leakage.
Incompatibilities: Strong oxidizing agents, acids, halogens.
Occupational Exposure Limits: No OSHA or ACGIH exposure limits for TPA specified; sample air routinely for amines if practical.
Engineering Controls: Use fume hood, local exhaust, or adequate general ventilation to keep exposure levels below recommended limits.
Personal Protective Equipment (PPE): Wear safety goggles, face shield, chemical-resistant gloves (nitrile or neoprene), and protective clothing. Use an approved respirator if vapor concentration exceeds safe levels.
Hygiene Measures: Do not eat, drink, or smoke near this chemical. Wash hands thoroughly after handling. Remove contaminated clothing and wash before reuse.
Environmental Controls: Use closed systems whenever possible. Do not allow run-off to reach local sewers or waterways.
Appearance: Clear, colorless to slightly yellow liquid
Odor: Fishy, amine-like
Odor Threshold: Not available
pH: Alkaline
Melting Point/Freezing Point: -70°C (-94°F)
Boiling Point/Range: 156-159°C (313-319°F)
Flash Point: 38°C (100°F) (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable
Explosion Limits: 1.0% - 5.8% (v/v in air)
Vapor Pressure: 4 mm Hg at 20°C
Vapor Density: 4.4 (air = 1)
Relative Density: 0.765 g/cm³ at 20°C
Solubility: Slightly soluble in water, miscible with most organic solvents
Partition Coefficient (n-octanol/water): log Kow ~2.4
Auto-ignition Temperature: 215°C (419°F)
Decomposition Temperature: Not determined
Viscosity: Not determined
Chemical Stability: Stable under standard temperatures and pressures.
Hazardous Reactions: Reacts with strong oxidizers to form explosive mixtures; reacts vigorously with acids producing heat.
Conditions to Avoid: Heat, sparks, open flames, static electricity, moisture, and incompatible chemicals.
Incompatible Materials: Oxidizing agents, acids, halogens.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, other toxic gases.
Acute Toxicity: Oral LD50 (rat): 935 mg/kg; Dermal LD50 (rabbit): 1456 mg/kg
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Symptoms: Irritation of eyes, skin, respiratory tract; dizziness and headache; nausea; drowsiness; high exposure may lead to unconsciousness
Chronic Effects: Long-term exposure could result in liver, kidney, or nervous system effects in some cases
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA
Reproductive Toxicity: Data insufficient for evaluation
Other Data: Prolonged or repeated exposure may cause allergic reactions in sensitive individuals
Toxicity to Aquatic Organisms: Harmful to aquatic life; LC50 (fish, 96h): ~68 mg/L
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulative Potential: Moderate potential, estimated log Kow 2.4
Mobility in Soil: Expected to be moderately mobile; possible leaching to groundwater in significant spills
Other Adverse Effects: Releases above reportable quantities may require notification of authorities due to toxicity to aquatic life
Disposal Methods: Collect and transfer into suitable containers for recovery or disposal at an approved facility. Do not dispose down the drain.
Contaminated Packaging: Empty containers may retain hazardous residues. Do not reuse. Dispose as hazardous waste.
Special Considerations: Comply with all local, state, and federal regulations governing disposal of chemical wastes.
Other Information: Consult licensed waste disposal contractor for safe, compliant handling.
UN Number: UN 1993
Proper Shipping Name: Flammable liquid, n.o.s. (Tripropylamine)
Hazard Class: 3 (Flammable liquid)
Packing Group: III
Label: Flammable Liquid
Environmental Hazards: Not classified as a marine pollutant
Transport Precautions: Keep containers upright and tightly closed during transport. Store away from incompatible materials.
Special Transport Notes: Emergency procedures apply for leaks, spills, or fire during transit. Check specific country or carrier requirements.
TSCA (US): Listed on the Toxic Substances Control Act inventory
DSL/NDSL (Canada): Listed
REACH (EU): Registered substance
SARA Title III: Not subject to reporting under Section 313
OSHA Hazard Symbols: Irritant, Flammable
WHMIS (Canada): B2 (Flammable liquid), D2B (Toxic/irritant)
Other Regulations: Workers must be properly trained in handling and emergency procedures as per local workplace legislation.
Chemical Safety Assessment: Has been carried out for industrial use as per EU guidance.
